While giving Ryan Seacrest a clear warning.

on Apr 20, 2012 - The Dish

Kathy Griffin speaks highly of someone in Hollywood? Now we know the world must be coming to an end. (Well played, Mayans, well played.)

Kidding aside, Kathy applauds her blonde comedy comrade Chelsea Handler for her handiwork pushing celebrities’ buttons, in the fiery redhead's tribute to Chelsea in this year's edition of the Time 100. “Few women in comedy have gotten the attention and respect of the Establishment. Chelsea has, while being raw, hilarious and unafraid to cross the line — and take it from me, that combination doesn't always go over.” 

Hoping to follow in Chuy’s leading lady’s pass-the-vodka footsteps, Kathy -- a freshly-dubbed talk show host herself -- continued raving, “What I love about Chelsea, 37, is that she gets the joke. She has not bought into the Hollywood myth that celebrities walk on water. She's still a trash-talking gal from Jersey. Sure, she's an extremely wealthy trash-talking gal from Jersey, but her authenticity is 100 proof.”

And, Ryan Seacrest, here’s a direct message for you, buddy. “If you're reading this, remember: it won't be long before Chelsea can buy and sell you,” Kathy cautions. Noted, K. “Yes @kathygriffin, I'm reading this…buy, sell, hell I'd lease,” Ryan fired back

Check out a clip of Kathy making Chelsea proud during the premiere of Kathy. (Although, NeNe Leakes, you may want to sit this one out.)