Abby McCarthy (Lisa Edelstein), famous author of the best-selling Girlfriends' Guide. . . mommy advice book series, has been living a lie. She's been hiding from her fans, friends, and family that she's separated from her husband. Now that her husband is actively dating, she begins to take the advice of her divorced friends (Janeane Garofalo, Beau Garrett) which leads to some unexpected and life-changing experiences.