Focused on living life to the fullest, Gail Greenberg is married to one of the top plastic surgeons in New York and is committed to keeping their love alive after having experienced one unsuccessful marriage. Fearful of drifting apart in a relationship again, Gail is concerned that she doesn’t fit in to her workaholic husband’s schedule and tries to find ways to incorporate herself in to his world. She has a type-A perfectionist personality from her family to her appearance, fitness to her fashion and always strives to be the best version of herself. Gail’s friendships mean everything to her, but despite their decade long-history, some might come to a head. Can the sisterhood stick together and overcome this bump in the road?